Neupogen Caution For Usage

Incompatibilities: Neupogen should not be diluted with saline solutions.
Diluted filgrastim may be adsorbed to glass and plastic materials.
This medicinal product must not be mixed with other products except those mentioned in Special precautions for disposal and other handling as follows.
Special precautions for disposal and other handling: If required, Neupogen may be diluted in 5% glucose.
Dilution to a final concentration less than 0.2 MU (2 μg) per ml is not recommended at any time.
The solution should be visually inspected prior to use. Only clear solutions without particles should be used.
For patients treated with filgrastim diluted to concentrations below 1.5 MU (15 μg) per ml, human serum albumin (HSA) should be added to a final concentration of 2 mg/ml.
Example: In a final injection volume of 20 ml, total doses of filgrastim less than 30 MU (300 μg) should be given with 0.2 ml of 20% human albumin solution Ph. Eur. added.
Neupogen contains no preservative. In view of the possible risk of microbial contamination, Neupogen pre-filled syringes are for single use only. Neupogen vials are for single use only.
When diluted in 5% glucose solution, Neupogen is compatible with glass and a variety of plastics including PVC, polyolefin (a co-polymer of polypropylene and polyethylene) and polypropylene.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.