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Fluvoxamine tablets are contraindicated in combination with tizanidine and monoamine oxidase inhibitors (MAOIs) (see Interactions).
Treatment with fluvoxamine can be initiated: two weeks after discontinuation of an irreversible MAOI, or the following day after discontinuation of a reversible MAOI (e.g. moclobemide, linezolid).
At least one week should elapse between discontinuation of fluvoxamine and initiation of therapy with any MAOI.
Fluvoxamine immediate-release tablets should not be used in combination with pimozide and ramelteon (see Interactions).
Hypersensitivity to the active substance or to any of the excipients.
