Increased plasma conc w/ strong CYP3A inhibitors eg, boceprevir, cobicistat, conivaptan, itraconazole, ketoconazole, posaconazole, telaprevir, troleandomycin, voriconazole, ritonavir, paritaprevir w/ ritonavir & ombitasvir &/or dasabuvir, ritonavir w/ danoprevir, elvitegravir, indinavir, lopinavir, saquinavir, tipranavir; grapefruit. Decreased plasma conc w/ strong CYP3A inducers eg, rifampin, carbamazepine, enzalutamide, mitotane, phenytoin, St. John's wort; moderate CYP3A4 inducers. Reduced plasma conc of CYP3A substrates w/ narrow therapeutic indices eg, hormonal contraceptives, alfentanil, cyclosporine, dihydroergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus, tacrolimus; P-gp substrates w/ narrow therapeutic index eg, digoxin.