Lipo-Dox Caution For Usage

Instructions for use/handling: Precaution during handling: Caution must be exercised in handling pegylated liposomal doxorubicin.
Do not use material that shows evidence of precipitation or any other particulate matter.
The use of gloves is required.
If pegylated liposomal doxorubicin comes into contact with skin or mucosa, wash immediately and thoroughly with soap and water.
Pegylated liposomal doxorubicin should be handled and disposed of in a manner consistent with that of other anticancer products in accordance with local requirements.
Dilution of Lipo-dox: The appropriate dose of pegylated liposomal doxorubicin must be diluted in Dextrose 5% in Water prior to administration. Do not use any diluent other than Dextrose 5% in Water, or the presence of any bacteriostatic agent, such as benzyl alcohol, which will cause precipitation.
For doses <90mg, dilute in 250 ml of Dextrose 5% in Water, and for doses ≥90mg, dilute in 500ml of Dextrose 5% in Water. Unless specific compatibility data are available, pegylated liposomal doxorubicin should not be mixed with other drug in the same IV infusion bag, these drugs are incompatible.
The dilution of pegylated liposomal doxorubicin is red, translucent, and clear solution, and should be used immediately after dilution. If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and should not be longer than 24 hours at 2°C to 8°C.
Administration: Do not administer the undiluted solution.
This can be infused over 60 or 90 minutes as detailed in Dosage & Administration.
It is recommended that the pegylated liposomal doxorubicin infusion line should be connected through the side port of an intravenous infusion of Dextrose 5% in Water.
The infusion might be given through a peripheral vein. Do not use with in-line filters.
Incompatibilities: Do not mix with other drugs.