Monotherapy Adult & adolescent from 16 yr Initially 250 mg bd, may be increased to 500 mg bd after 2 wk then further increased by 250 mg bd every 2 wk. Max: 1,500 mg bd.
Add-on therapy Adult ≥18 yr & adolescent 12-17 yr, ≥50 kg Initially 500 mg bd, may be increased up to 1,500 mg bd. Dose changes can be made in 500 mg bd increases or decreases every 2-4 wk.
Childn 4-11 yr & adolescent 12-17 yr, 25-50 kg Initially 10 mg/kg bd, may be increased up to 30 mg/kg bd. Dose changes should not exceed 10 mg/kg bd increases or decreases every 2 wk.
Childn ≥50 kg Adult dose.