Not to be used long-term in patients w/ potential to have autologous stem cell transplantation. Not be given to patients who have recently undergone RT or received other cytotoxic agents. History of seizure disorders, patients on high pulse dosing regimens; lymphocytic bone marrow infiltration or hypoplastic bone marrow; chromatid or chromosome damage; acute secondary haematologic malignancies; significantly increased incidence of acute leukaemia. Monitor renal function, signs & symptoms of hepatic toxicity. Closely monitor blood counts during treatment. Not recommended w/ live organism vaccine in immunocompromised individuals. Renal & severe hepatic impairment. May impair fertility in women & men. Avoid use during pregnancy. Not to be used during lactation. Childn w/ nephrotic syndrome.
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