Lanzotred

Enzalutamide

Adult men w/ metastatic hormone-sensitive prostate cancer in combination w/ androgen deprivation therapy (ADT). Adult men w/ high-risk non-metastatic castration-resistant prostate cancer (CRPC). Adult men w/ metastatic CRPC who are asymptomatic or mildly symptomatic after failure of ADT in whom chemotherapy is not yet clinically indicated & whose disease has progressed on or after docetaxel therapy.

160 mg as single daily dose.

May be taken with or without food: Swallow whole w/ water. Do not chew/dissolve/open.

Hypersensitivity. Women of childbearing potential. Pregnancy.

Discontinue use if posterior reversible encephalopathy syndrome develops. Hypersensitivity reactions. Risk of seizures; recent CV disease. Not to be taken by patients w/ fructose intolerance. Avoid concomitant use w/ warfarin & coumarin-like anticoagulants. Concomitant use w/ cytotoxic chemotherapy. Monitor INR when co-administered w/ warfarin or acenocoumarol. May affect ability to drive & use machines. ESRD; severe renal & hepatic impairment. Men & women of childbearing potential should use effective contraception during & for 3 mth after treatment. Not to be used in women of childbearing potential. Not to be used during pregnancy & lactation.

Hot flush, HTN; fractures; asthenia, fatigue. Anxiety; headache, memory impairment, amnesia, attention disturbance, restless legs syndrome; ischemic heart disease; dry skin, pruritus; gynaecomastia; fall.

Increased AUC & decreased C_max w/ strong CYP2C8 inhibitors eg, gemfibrozil. Decreased AUC of midazolam, S-warfarin, omeprazole. Caution w/ analgesics (eg, fentanyl, tramadol), antibiotics (eg, clarithromycin, doxycycline), anticancer agents (eg, cabazitaxel), antiepileptics (eg, carbamazepine, clonazepam, phenytoin, primidone, valproic acid), antipsychotics (eg, haloperidol), antithrombotics (eg, acenocoumarol, warfarin, clopidogrel), β-blockers (eg, bisoprolol, propranolol), Ca-channel blockers (eg, diltiazem, felodipine, nicardipine, nifedipine, verapamil), cardiac glycosides (eg, digoxin), corticosteroids (eg, dexamethasone, prednisolone), HIV antivirals (eg, indinavir, ritonavir), hypnotics (eg, diazepam, midazolam, zolpidem), immunosuppressants (eg, tacrolimus), CYP3A4-metabolized statins (eg, atorvastatin, simvastatin), thyroid agents (eg, levothyroxine); P-gp substrates eg, colchicine, dabigatran etexilate, digoxin; BCRP, MRP2, OAT3, OCT1 substrates.

Cancer Hormone Therapy

L02BB04 - enzalutamide ; Belongs to the class of anti-androgens. Used in treatment of neoplastic diseases.

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