Increased hypotensive effects w/ diuretics & other antihypertensives. Higher frequency of adverse events w/ aliskiren-containing products or ACE inhibitors. Increased serum K levels w/ K-sparing diuretics, K supplements, K-containing salt substitutes or other medicinal products increasing serum K eg, heparin. Reversible increased serum lithium conc & toxicity. Attenuated antihypertensive effect w/ NSAIDs eg, selective COX-2 inhibitors, ASA (>3 g daily) & non-selective NSAIDs. Increased C
max & AUC of repaglinide.