Gynoflor Use In Pregnancy & Lactation

Gynoflor can be used in pregnancy and lactation. However, as with other medicinal products in general, caution should be exercised when prescribing Gynoflor to pregnant women in the 1st trimester.
Data on a limited number (54) of exposed pregnancies indicate no adverse effects of estriol and Lactobacillus acidophilus on pregnancy, or on the health of the foetus/newborn child. Furthermore, Gynoflor has been used for more than 15 years without apparent adverse effects.
Animal studies have shown harmful effects of estriol on male foetuses (see Pharmacology: Toxicology: Preclinical safety data under Actions). However, estriol is a sexual hormone which is specific for humans and is not found in other mammalian species. Thus, toxicological data from animal studies are of limited use and cannot be extrapolated to humans.
Gynoflor contains estriol only in a very low dose. It has been shown in non-pregnant women that after the 1st application of Gynoflor, the plasma concentration of estriol increases transiently, whereas after the 12th application, no increase was observed. After repeated application, the plasma concentration of estriol is within the normal range of postmenopausal women.
Furthermore, the maternal plasma concentration of estriol during pregnancy is increased about 1000 times as compared to non-pregnant women.