Edoxaban is used to reduce the risk of stroke and blood clots in people with irregular heart rhythm and at least one additional condition such as heart failure, high blood pressure or previous stroke. It may also be used to treat or prevent the recurrence of blood clots in your leg veins or lung artery.
Take Edoxaban exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
You may take this medicine with or without food. Try to take it at the same time each day.
If you have difficulty swallowing the tablets, you may crush the tablets and mix it with apple puree or 2-3 ounces of water. Stir and drink the suspension immediately.
Edoxaban must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
If a dose is missed, take the missed dose immediately on the same day then resume dosing the following day according to your normal dosing schedule.
DO NOT double a dose under any circumstances.
If you often forget to take your medicine, let your doctor and pharmacist know.
Alert your doctor if you have the following conditions:
- active bleeding
- uncontrolled severe high blood pressure
- other conditions that may increase the risk of bleeding e.g. history of stomach ulcers, recent brain or spinal injury, tumours or blood vessel abnormalities
- liver disease which leads to an increased risk of bleeding
as Edoxaban may not be suitable for you.
Do not take this medicine if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with Edoxaban, alert your doctor immediately. This medicine may cause harm to your unborn child. You must use proven birth control methods while taking Edoxaban.
Do not take this medicine if you are breastfeeding.
Alert your doctor if you have recently undergone surgery on the eyes, brain, or spine.
Do not take Edoxaban with other blood-thinning medicines such as warfarin, apixaban or heparin (except when changing your blood-thinning treatment). Please see the section "Can I take this with other medicines?" below for more information.
Inform your doctor if you have the following conditions:
- bleeding problems
- liver disease
- kidney disease
- heart disease
- have mechanical (surgically implanted) heart valve
If you are going to have an operation, dental work, minor surgery, any procedure involving a catheter or an injection into your spinal column (e.g. spinal or epidural anaesthesia), or cardioversion (a procedure used to restore regular heart rhythm), inform your doctor or dentist that you are taking Edoxaban.
Why is it important to keep my appointments with the doctor?
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
- Routine tests (e.g. liver and kidney function) may be done before and during treatment with this medicine. Your doctor will advise you about how often you need to have these tests.
- Regular monitoring of signs of blood loss may also be needed.
Edoxaban may cause any of the following side effects: stomach pain, headache, dizziness, rash, and itching.
This medicine will cause you to bleed more easily. Alert your doctor if you get any unusual bruising (large bruises or several bruises especially if they appear by themselves or if they cover a large area), or bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth). Alert your doctor if you notice blood in your urine or stool or if you get a nosebleed.
Edoxaban may cause the level of your red blood cells to drop.
Red blood cells carry oxygen around your body. A fall in the level of red blood cells may make you feel tired and worn out.
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Do not take Edoxaban with the following medicines:
- other blood-thinning medicines e.g. warfarin, apixaban, heparin (except when changing your blood-thinning treatment)
- NSAIDs (medicines for pain and inflammation) e.g. naproxen
- medicines to treat depression e.g. fluoxetine, venlafaxine
- rifampicin (medicine to treat TB [lung infection known as tuberculosis])
Inform your doctor and pharmacist if you are taking any of these medicines:
- ciclosporin (medicine used in organ transplant or certain immune disorders)
- ketoconazole (medicine to treat fungal infection)
- erythromycin (antibiotic)
- medicines for heart disease e.g. dronedarone, verapamil, quinidine
- medicines for epilepsy (fits or seizures) e.g. phenytoin, carbamazepine, phenobarbital
- St. John’s wort (herbal medicine)
This list does not include all medicines that may interact with Edoxaban.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.
Avoid alcohol.
Store in a cool, dry place away from the reach of children.
Medicines must not be used past the expiry date.
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