Not to be used in patients w/ history of, current signs &/or clinical symptoms of resp or cardiac disorders linked to fibrotic tissue. Severe CV disease, Raynaud's syndrome, peptic ulcer, GI bleeding, history of serious (particularly psychotic) mental disorders; postural hypotension. Pleuro-pulmonary disease eg, dyspnea, shortness of breath, persistent cough or chest pain; urethral/abdominal vascular obstruction; cardiac failure. Somnolence/sudden sleep onset in Parkinson's disease. Psychiatric disorders. Perform CV evaluation, measure erythrocyte sedimentation rate, serum creatinine measurements, lung function/chest X-ray & renal function, complete pituitary evaluation prior to therapy. Long-term use. Concomitant use w/ other drugs lowering BP. May affect ability to drive & use machines. Renal & severe hepatic insufficiency. Not to be used in women w/ pregnancy-induced HTN (eg, preeclampsia or postpartum HTN). Avoid use during pregnancy. Not to be used during lactation. Childn <16 yr. Elderly w/ hyperprolactinemic disorders.
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