Domperidone - oral

Patient Medicine Information
Why do I need this medicine?
Domperidone helps relieve nausea and vomiting in adults and adolescents (12 years of age and older) weighing 35 kg or more.

This medicine may be used to treat other conditions as decided by your doctor.
How do I take this medicine?
Take Domperidone exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Take it on an empty stomach, at least 15-30 minutes before a meal. Try to take it at the same time each day.

This medicine is available as a tablet or oral suspension.

If you are taking the oral suspension, shake the bottle well before you take it to ensure that the liquid is evenly mixed. Use the measuring cup or oral syringe provided to measure your dose. Refer to the package insert for directions on how to use the oral syringe.

You may stop taking this medicine when you no longer have nausea or vomiting.

Do not take this medicine for more than 1 week unless instructed by your doctor.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.
When should I not use this medicine?
Alert your doctor if you have the following conditions:
  • prolactinoma (a tumour of the pituitary gland that overproduces a hormone called prolactin which stimulates the breast to produce milk)
  • heart disease e.g. heart rhythm disorder, heart failure (weakness and inability of the heart to pump blood)
  • significant disturbances of essential mineral in the body e.g. low or high potassium levels in the blood, low magnesium levels in the blood
  • stomach or bowel problems e.g. stomach bleeding, bowel blockage, tear in the intestines
  • moderate or severe liver disease
as Domperidone may not be suitable for you.

Do not take Domperidone with medicines for irregular heartbeat, HIV and fungal infections, and certain antibiotics. Please see the section "Can I take this with other medicines?" below for more information.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • personal or family history of breast cancer
  • risk factors for sudden stopping of the heart e.g. family history of heart disease, high blood pressure, high cholesterol level, diabetes, smoking, excessive alcohol consumption
  • kidney disease
  • mild liver disease
Let your doctor know if you are pregnant or breastfeeding.

Be sure to check with your doctor or pharmacist before giving Domperidone to a child or an elderly. Children and elderly people may be more sensitive to the side effects.

For as long as you are taking this medicine, you may need to have regular tests such as ECG (a test used to record the electrical activity of the heart) and kidney function tests, to check your body’s response to the medicine. Your doctor will advise you about how often you will need to have these tests.
What side effects could I experience?
Domperidone may cause any of the following side effects: headache, sleepiness, dry mouth, diarrhoea, weakness, rash, itching, breast pain and tenderness, and loss of sexual desire.

Some women may experience milk secretion unrelated to breastfeeding while some men may experience breast enlargement. Discuss with your doctor if you are concerned about these side effects.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • fast, irregular, or abnormal heartbeat
  • chest pain or pressure
  • uncontrollable movements such as irregular eye or tongue movements, abnormal posture like twisted neck, trembling and muscle stiffness
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Do not take Domperidone if you are taking any of these medicines:
  • medicines for irregular heartbeat e.g. disopyramide, amiodarone
  • medicines for mood disorders e.g. haloperidol, pimozide, sertindole
  • medicines to treat depression e.g. citalopram, escitalopram, nefazodone
  • medicines for cold or allergy e.g. mequitazine, mizolastine
  • medicines for stomach problems e.g. cisapride, dolasetron, prucalopride
  • medicines for cancer e.g. toremifene, vandetanib, vincamine
  • medicines for HIV infection e.g. ritonavir, atazanavir, indinavir
  • medicines to treat fungal infection e.g. ketoconazole, fluconazole, voriconazole
  • certain antibiotics e.g. erythromycin, clarithromycin, pentamidine, levofloxacin, spiramycin
  • medicines for malaria e.g. halofantrine, lumefantrine
  • methadone (strong painkiller)
  • bepridil (medicine for high blood pressure)
  • aprepitant (medicine used to prevent nausea and vomiting caused by cancer drugs)
This list does not include all medicines that may interact with Domperidone.

This medicine should not be taken with antacids or other medicines that reduce stomach acid (e.g. cimetidine, sodium bicarbonate) as these medicines could reduce the effectiveness of Domperidone. If you must take these medicines, take them between meals after you have taken Domperidone.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.

Avoid excessive consumption of grapefruit or grapefruit juice (more than 1 litre a day).
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Protect from light and moisture.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on domperidone - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by
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