Diazon Mechanism of Action

Pharmacotherapeutic group: Antifungal (Topical).
Pharmacology: Fungistatic; may be fungicidal, depending on concentration; azole antifungals interfere with cytochrome P450 enzyme activity, which is necessary for the demethylation of 14-alpha-methylsterols to ergosterol. Ergosterol, the principal sterol in the fungal cell membrane, becomes depleted. This damages the cell membrane, producing alterations in membrane functions and permeability. In candida albicans, azole antifungals inhibit transformation of blastospores into invasive mycelial form.
High dose Ketoconazole therapy can interfere with conversion of lanosterol to cholesterol, a major precursor of several hormones. It has been shown to suppress corticosteroid secretion and lower serum testosterone concentrations, which return to baseline values when Ketoconazole is discontinued.
Pharmacokinetics: Absorption: After a single topical application of Ketoconazole cream to the chest, back, and arms of normal volunteers, systemic absorption of Ketoconazole was not detected during the following 72 hour period, using a minimum detection level of 5 nanograms per ml in blood.