Hypersensitivity to the active substance(s) or to any of the excipients.
Hypercalcaemia and/or hypercalciuria.
Nephrolithiasis and/or nephrocalcinosis.
Serious renal impairment.
Pseudohypoparathyroidism as the vitamin D requirement may be reduced due to phases of normal vitamin D sensitivity, involving the risk of prolonged overdose. Better-regulatable vitamin D derivatives are available for this.