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Pharmacotherapeutic group: paramagnetic contrast media for MRI. ATC code: V08CA02 (gadoteric acid).
Pharmacology: Pharmacodynamics: Cyclolux has paramagnetic properties allowing MRI contrast enhancement. It has no specific pharmacodynamic activity and is biologically very inert.
Pharmacokinetics: Following intravenous injection, gadoteric acid is mainly distributed in the extracellular fluid. It is not bound to plasma albumin. In patients with normal renal function, the plasma half-life is about 90 minutes. Gadoteric acid is eliminated in unchanged form by glomerular filtration.
Plasma clearance is delayed in patients with impaired renal function.
A small amount of gadoteric acid is excreted in breast milk and crosses the placenta.
