Linked to perindopril: Hypersensitivity to the active substance or to any other ACE inhibitor,
History of angioedema associated with previous ACE inhibitor therapy,
Hereditary or idiopathic angioedema,
Second and third trimesters of pregnancy (see Precautions and Use in Pregnancy & Lactation),
Concomitant use of Coveram with aliskiren-containing products in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/1.73 m2) (see Interactions and Pharmacology: Pharmacodynamics under Actions),
Concomitant use with sacubitril/valsartan therapy. Coveram must not be initiated earlier than 36 hours after the last dose of sacubitril/valsartan. (see Precautions and Interactions),
Extracorporeal treatments leading to contact of blood with negatively charged surfaces (see Interactions),
Significant bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney (see Precautions).
Linked to amlodipine: Severe hypotension,
Hypersensitivity to the active substance or to dihydropyridines derivatives,
Shock, including cardiogenic shock,
Obstruction of the outflow-tract of the left ventricle (e.g. high grade aortic stenosis),
Haemodynamically unstable heart failure after acute myocardial infarction.
Linked to Coveram: All contraindications related to each monocomponent, as previously mentioned, should apply also to the fixed combination of Coveram.
Hypersensitivity to any of the excipients listed in Description.