Concor must not be used in patients with: acute heart failure or during episodes of heart failure decompensation requiring intravenous therapy with substances increasing the contractility of the heart, shock induced by disorders of cardiac function (cardiogenic shock), severe disturbances of atrioventricular conduction (second or third degree AV block) without a pacemaker, sick sinus syndrome, sinoatrial block, slowed heart rate, causing symptoms (symptomatic bradycardia), decreased blood pressure, causing symptoms (symptomatic hypotension), severe bronchial asthma, severe forms of peripheral arterial occlusive disease or Raynaud's syndrome, untreated tumours of the adrenal gland (phaeochromocytoma), metabolic acidosis, hypersensitivity to bisoprolol or to any of the excipients (see Description).