Cerezyme is administered by IV infusion >1-2 hrs. Dosage should be individualized to each patient. Initial dosages range from 2.5 U/kg of body weight 3 times weekly to 60 U/kg once every 2 weeks. 60 U/kg every 2 weeks is the dosage for which the most data are available. Disease severity may dictate that treatment be initiated at a relatively high dose or relatively frequent administration. Dosage adjustments should be made on an individual basis, and may increase or decrease, based on achievement of therapeutic goals as assessed by routine comprehensive evaluations of the patient's clinical manifestations.
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