Bisodac-HF Mechanism of Action

Pharmacology: Pharmacodynamics: Bisoprolol, the active ingredient of BISODAC-HF is a beta l- selective-adrenoceptor blocking agent, lacking intrinsic stimulating and relevant membrane stabilizing activity. It only shows very low affinity to the beta 2-receptor of the smooth muscles of bronchi and vessels as well as to the beta2 -receptors concerned with metabolic regulation. Therefore, bisoprolol is generally not to be expected to influence the airway resistance and beta2-mediated metabolic effects. Its beta 1 selectivity extends beyond the therapeutic dose range.
Pharmacokinetics: Absorption: Bisoprolol is almost completely absorbed from the gastrointestinal tract and undergoes only minimal first-pass metabolism resulting in an oral bioavailability of about 90%. Peak plasma concentrations occur 2 to 4 hours after oral doses.
Distribution: Bisoprolol is about 30% bound to plasma proteins. Bisoprolol is moderately lipid-soluble.
Metabolism: It is metabolised in the liver.
Elimination: It has a plasma elimination half-life of 10 to 12 hours.
It is excreted in urine, about 50% as unchanged drug and 50% as metabolites.