Discontinue use if allergic or anaphylactic-type reactions occur. Hypervolaemia or haemodilution eg, CHF, HTN, oesophageal varices, pulmonary oedema, hemorrhagic diathesis, severe anaemia, renal or post-renal anuria. Discontinue use at 1st clinical sign of CV overload or increased BP, central venous pressure or pulmonary oedema. Patients on controlled Na diet. Monitor patient's electrolyte status. Ensure adequate substitution of other blood constituent in large vol replacement eg, coagulation factors, electrolytes, platelets & erythrocytes. 25%: Ensure adequate hydration. Monitor patients against circulatory overload & hyperhydration.