Control & prevention of hemorrhagic episodes & for routine & surgical prophylaxis in patients w/ haemophilia A (congenital factor VIII deficiency/classic haemophilia).
Individualised dosage. Bleeding & surgery: Minor 20-40 IU/dL every 12-24 hr for at least 1 day, depending on the severity of the hemorrhage. Moderate 30-60 IU/dL infusion every 12-24 hr for 3-4 days or until adequate wound healing. Tooth extraction 30-60 IU/dL single infusion + oral antifibrinolytic therapy w/in 1 hr. Major 60-100 IU/dL infusion every 8-24 hr until threat is resolved or until adequate wound healing in the case of surgery, followed by at least another 7 days therapy. Previously treated adult & adolescentProphylaxis 30 ± 5 IU/kg given 3 times wkly.
Not indicated in patients w/ Von Willebrand's disease. Discontinue immediately if allergic or anaphylactic reactions occur; appropriate medical management should be given. Perform an assay to determine presence of factor VIII inhibitors if plasma levels are not attained or bleeding is not controlled w/ an appropriate dose. Administered to pregnant & lactating women only if clearly indicated.
Factor VIII inhibition (PUPs), headache, cough, arthralgia, pyrexia. Factor VIII inhibition (PTPs), decreased appetite, dizziness, haemorrhage; haematoma, diarrhoea; vomiting; abdominal pain; nausea, urticaria; rash; pruritus, myalgia, chills; catheter site related reaction, Ab test +ve; anti-factor VIII Ab +ve; human anti-mouse Ab +ve; abnormal LFT.
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