Concomitant use of 2 or more β-adrenergic blocking agents, prostaglandins, prostaglandin analogs or prostaglandin derivatives. Mydriasis occurs when given w/ epinephrine. Potential for additive effects resulting in hypotension &/or marked bradycardia w/ oral Ca-channel blockers, guanethidine or β-blocking agents, antiarrhythmics, digitalis glycosides & parasympathomimetics. Potentiated systemic β blockade (eg, decreased heart rate, depression) w/ CYP2D6 inhibitors (eg, quinidine, fluoxetine, paroxetine) & timolol. The hypertensive reaction to sudden w/drawal of clonidine can be potentiated when taking β-blockers. β-blockers may increase hypoglycemic effect of antidiabetic agents & mask signs/symptoms of hypoglycaemia.