250-500 mg once daily for 7-14 days. Renal impairment w/ CrCl 20-49 mL/min Initially 500 mg, followed by 250 mg/24 hr; CrCl 10-19 mL/min & haemodialysis patient (chronic ambulatory peritoneal dialysis) Initially 500 mg, followed by 250 mg/48 hr; CrCl 50-80 mL/min No need to adjust dose.
Administration
Should be taken on an empty stomach: Take 1 hr before or 2 hr after meals. Ensure adequate fluid intake.
Contraindications
Hypersensitivity to levofloxacin or other quinolone derivatives. Pregnancy & lactation. Childn <18 yr.
Special Precautions
Patients w/ renal dysfunction, sensitivity to nerve disturbance. Long-term use may cause overgrowth of nonsusceptible microorganisms. Periodic exam for liver, renal & hematopoietic function should be done. Monitor blood glucose level when concomitantly used w/ antihypoglycaemic agents. Elderly may require lower dose.
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