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Treatment of overdosage of folic acid antagonists: In cases of overdosage of folic acid antagonists Folinic Acid 10 mg/m2 may be administered i.v. or i.m. every 6 hours until the serum concentration Methotrexate under 10-8 M. In general, where overdosage is susceptible, the dose of Folinic Acid should be equal to or higher than the offending dose of the folic acid antagonists administered, and should be given as soon as possible; preferably within the first hour, after which it is much less effective.
Treatment of megaloblastic anaemia: For treatment of megaloblastic anaemia, the dose should not exceed 1 mg daily given intramuscularly or orally.
