Usual dose: 250-500 mg once daily for 7-14 days orally or by slow infusion over 60 min every 24 hr or 750 mg by slow infusion over 90 min every 24 hr.
Acute bacterial exacerbation of chronic bronchitis 500 mg daily orally or by infusion for 7 days or 750 mg by infusion for 3-5 days.
Community-acquired pneumonia 500 mg daily orally or by infusion for 7-14 days or 750 mg by infusion for 5 days.
Acute maxillary sinusitis 500 mg daily orally for 10-14 days.
Acute bacterial sinusitis 500 mg by infusion for 7-14 days or 750 mg for 5 days.
Uncomplicated skin & skin structure infections 500 mg daily for 7-10 days.
Nosocomial pneumonia 750 mg by infusion for 7-14 days.
Complicated UTI & acute pyelonephritis 250 mg daily for 10 days orally or 250-750 mg by infusion once daily depends on the type & severity of the presumed causative pathogen usually for 7-14 days.
Chronic bacterial prostatitis 500 mg by infusion for 28 days.
Acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, acute maxillary sinusitis, uncomplicated skin & skin structure infections Patient w/ CrCl >50 mL/min Initially 250 mg by infusion 24 hrly followed by 500 mg 24 hrly,
CrCl 20-50 mL/min 250 mg by infusion 24 hrly,
CrCl 20-49 mL/min Initially 500 mg orally followed by 250 mg 24 hrly,
CrCl 10-19 mL/min Initially 500 mg followed by 250 mg 48 hrly.
Hemodialysis & chronic ambulatory peritoneal dialysis patient Initially 500 mg orally followed by 250 mg 48 hrly.
Complicated UTI & acute pyelonephritis Patient w/ CrCl 10-19 mL/min Initially 250 mg followed by 250 mg 48 hrly.
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