Consider renal function assessment during routine follow-up in patients treated w/ 40-mg dose. Patients who consume excessive quantities of alcohol &/or have a history of liver disease; w/ secondary hypercholesterolemia caused by hypothyroidism or nephrotic syndrome; w/ predisposing factors for myopathy/rhabdomyolysis. Perform liver function tests prior to initiation of therapy & 3 mth later. Report promptly inexplicable muscle pain, weakness or cramps, particularly if associated w/ malaise or fever. Monitor marked creatinine kinase elevations. Hypothyroidism, history of hereditary muscular disorders, muscular toxicity w/ another HMG-CoA reductase inhibitor or fibrate, alcohol abuse, concomitant use of fibrates. Additional neuromuscular & serologic testing may be necessary. Increased HbA1c, serum glucose & plasma level. Concomitant administration w/ products that interact w/ protein transporter (eg, OATP1B1 & BCRP). Patient known to have c.521CC or c.421AA genotype. May impair ability to drive or operate machinery. Renal impairment. Childn. Elderly >70 yr.