Timipen Dosage & Drug Information

Concise Prescribing Info Bahasa Concise Prescribing Info

Concise Prescribing Info

Contents

Imipenem 500 mg, cilastatin Na 500 mg

Indications/Uses

Intra-abdominal, lower resp tract, gynecological, GUT, skin & soft tissue infections, septicemia, endocarditis.

Dosage/Direction for Use

Adult Treatment Usual dose 1-2 g daily in 3-4 divided dose. Max: 50 mg/kg/day or 4 g/day. Prophylaxis 1 g on induction of anesth w/ another 1 g 3 hr later. For high-risk surgery 2 additional 500 mg doses 8 & 16 hr after induction.

Contraindications

Hypersensitivity to imipenem & cilastatin

Special Precautions

History of GI disease, impaired kidney disease. May cause partial cross-allergic reactions w/ penicillin & cephalosporin. Pregnancy & lactation.

Adverse Reactions

Erythema, local pain, thrombophlebitis, rash, pruritus, urticaria, TEN, fever, anaphylactic reactions, nausea, vomiting, diarrhea, pseudomembranous colitis, eosinophilia, leucopenia, neutropenia, agranulocytosis, thrombocytopenia, thrombocytosis, reduced Hb, hepatitis (rare). Direct +ve result in Coombs' test. Oliguria/anuria, polyuria, acute kidney failure (rare), myoclonic activity, psychic disturbance, confusion, convulsion, taste disturbance.

View ADR Monitoring Form

Drug Interactions

Ganciclovir, probenecid, lactic soln.

MIMS Class

Other Beta-Lactams

ATC Classification

J01DH51 - imipenem and cilastatin ; Belongs to the class of carbapenems. Used in the systemic treatment of infections.

Presentation/Packing

Form

Timipen inj

Packing/Price

1's

Timipen

imipenem + cilastatin

Manufacturer:

Interbat