AdultConservative treatment of hyperthyroidism: Complete thyroid hormone blockade production Initially 25-40 mg daily. Max daily dose: 40 mg in single dose of 20 mg max. Mild cases: 10 mg twice daily. Severe cases: 20 mg twice daily. Maintenance: Reduce dose to 5-20 mg daily (usually requires additional administration of thyroid hormones). 2nd dosage regimen: Monotherapy Usually 2.5-10 mg daily. Prep for surgery in all forms of hyperthyroidism Attain normal metabolic activity of thyroid gland. Perform surgery as soon as this is achieved. Otherwise, administer supplementary thyroid hormones. In the last 10 days before surgery, iodine may be administered to consolidate the thyroid tissue. Treatment before radioiodine therapy Attain normal metabolic activity of thyroid gland. Higher radioiodine doses may be necessary. Childn Initially 0.3-0.5 mg/kg/day. Maintenance: 0.2-0.3 mg/kg/day. Additional thyroid hormone treatment may be required. Pregnant women 2.5-10 mg daily w/o thyroid hormone. Patient w/ liver damage Low dose as possible.
View Thyrozol overdosage for action to be taken in the event of an overdose.
Administration
Should be taken with food.
Contraindications
Hypersensitivity. Granulocytopenia, cholestasis existing before start of therapy, previous damage to bone marrow after treatment w/ carbimazole or thiamazole.
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