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Sucralfate is a complex formed from Sucrose Octasulphate and Polyaluminum hydroxide. Its anti-ulcer activity is the result of ulcer-adherent protein-Sucralfate complex that covers the ulcers site and protects it against further attack of acid, pepsin, and bile salts.
Laboratory and clinical studies indicate that Sucralfate may promote the healing of peptic ulcers in 3 ways: 1. Forming a chemical complex that binds to the ulcer site to establish a protective barrier.
2. Inhibits the actions of acid, pepsin, and bile.
3. Blocking the diffusion of gastric acid through the barrier of Sucralfate-Albumin.
Studies indicate that Sucralfate remains in the GI tract for extended periods, prolonging the therapeutic actions of the drug. Furthermore, Sucralfate is minimally absorbed from the GI tract which results insignificant side effects.
