Stablon Use In Pregnancy & Lactation

Pregnancy: In a peri- and postnatal study, increased post-implantation and post natal losses were observed in rats at a maternotoxic dose (see Pharmacology: Toxicology: Preclinical safety data under Actions).
There are no or limited data (less than 300 pregnancy outcomes) from the use of tianeptine in pregnant women. Therefore, it is preferable not to use tianeptine during pregnancy whatever the term.
It is preferable to maintain a balanced maternal psychic equilibrium throughout pregnancy. If tianeptine is necessary to ensure this balance, treatment should be initiated or continued at the necessary dose throughout pregnancy and if possible as monotherapy and the pharmacological profile of the molecule should be taken into account when monitoring the newborn baby.
Lactation: Dysgalactia in the dams was observed in rats at a maternotoxic dose (see Pharmacology: Toxicology: Preclinical safety data under Actions).
Tricyclic antidepressants are excreted into breast milk, and thus breast feeding is not recommended during treatment.
Fertility: In rats, a fertility study showed decreased reproductive performances (increase in preimplantation losses) at a maternotoxic dose (see Pharmacology: Toxicology: Preclinical safety data under Actions).
In humans, no clinical data are available.