Adult 2-4 g daily 12 hrly. Dose may be increased up to 8 g daily in severe or refractory infections. Max daily dose: 4 g. Childn 40-80 mg/kg/day in divided doses every 6-12 hr. Dose may be increased up to 160 mg/kg/day in severe or refractory infections administered in 2-4 equally divided doses. Neonate May be given in the 1st wk of life 12 hrly. Max: 80 mg/kg/day.
Contraindications
Hypersensitivity to penicillins, sulbactam, cefoperazone or any of the cephalosporins.
Special Precautions
Vit K deficiency in patient w/ poor diet, malabsorption states (cystic fibrosis) & prolonged IV alimentation regimen. Monitor prothrombin time & those receiving anticoagulant therapy. Overgrowth of nonsusceptible organisms in prolonged use. Periodic monitoring for organ system dysfunction during extended therapy eg, renal, hepatic & hematopoietic system. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn.
J01DD62 - cefoperazone and beta-lactamase inhibitor ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
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