As adjunct to diet for reduction of elevated total cholesterol, LDL-C, Apo B, & triglycerides in patients w/ primary hypercholesterolemia, hyperlipidemia, combined homozygous & heterozygous familial hypercholesterolemia if response to diet & other non-pharmacology parameter is not sufficient. Childn 10-17 yr: Adjunct to diet to reduce total cholesterol, LDL-C, Apo B in boys & postmenarchal girls 10-17 yr w/ heterozygous familial hypercholesterolemia if after an adequate trial of diet therapy, the following findings are present: LDL-C remains ≥190 mg/µL or ≥150 mg/µL & there is a positive family history of premature CV disease or ≥2 other CV disease risk factors.
Dosage/Direction for Use
Usual dosage range: 10-80 mg once daily. Initially 10 mg once daily. Combined homozygous & heterozygous familial hypercholesterolemia 10 mg one daily. Homozygous familial hypercholesterolemia 80 mg. Heterozygous familial hypercholesterolemiaChildn 10-17 yr Initially 10 mg daily. Max: 20 mg daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Liver disease or persistent elevated serum transaminase >3 times the upper limit of normal. Pregnancy & lactation.
Special Precautions
Liver function test should be performed prior to initiation of treatment, 12 wk following both the initiation of therapy & any evaluation of dose & periodically thereafter. Monitor creatine phosphokinase & transaminase elevations. Increased risk of myopathy in concurrent administration w/ cyclosporine, fibric acid derivative, erytrhomycin, niacin or azole antifungals. Temporary suspension of atorvastatin may be appropriate in serious acute myopathy or patients who have a risk factor for secondary kidney failure to rhabdomyolysis.
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