Simryl

Glimepiride

NIDDM (type 2 DM) inadequately controlled by diet, exercise & wt reduction program.

Initial dose & dose titration: 1 mg once daily. May be increased at intervals of 1-2 wk, carried out stepwise as follows: 1 mg-2 mg-3 mg-4 mg-6 mg, & in exceptional cases, 8 mg.

Should be taken with food: Take immediately before the 1st main meal of the day. Do not skip meals.

Hypersensitivity to glimepiride, other sulfonylurea, sulfonamide, have a risk of hypersensitivity reactions. IDDM, diabetic ketoacidosis or a history of diabetic ketoacidosis, diabetic coma or precoma. Liver & kidney dysfunction. Pregnancy & lactation.

Increased risk of hypoglycemia in case of unwillingness, irregular meal times, undernutrition fasting, change of dietary pattern, alcohol consumption. Overdose, endocrine disorders affecting carbohydrate metabolims eg, thyrotoxicosis. Impaired kidney function. Severe liver dysfunction.

Hypoglycemia, visual disturbances, nausea, vomiting, feeling of fullness in the epigastrium, abdominal pain, diarrhea, liver dysfunction, hemolytic anemia, erythrocytopenia, leucopenia, granulocytopenia, agranulocytosis, thrombocytopenia, pancytopenia, allergic reactions eg, urticaria or skin redness which may continue or accompanied w/ apnea & hypotension up to shock.

Insulin, other oral antidiabetic drugs, ACE inhibitor, allopurinol, anabolic steroid, sex hormones, chloramphenicol, coumarin derivative, MAOIs, miconazole, paracetamol, pentoxifylline (high parenteral dose), phenylbutazone, azopropazone, oxyphenbutazone, probenecid, quinolone, salicylate, sulfipyrazone, sulphonamide, tetracycline, tritoqualine, trofosfamide, acetazolamide, barbiturate, corticosteroid, diazoxide, diuretics, epinephrine (adrenaline), other sympathomimetic drugs, glucagon laxative, nicotinic acid (high dose), estrogen, progesterone, phenothiazine, rifampicin, thyroid hormone, H₂ receptor antagonist, clonidine, reserpine, β receptor antagonist, clonidine, guanethidine, coumarin derivative, alcohol.

Antidiabetic Agents

A10BB12 - glimepiride ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.

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