Simprazol

Esomeprazole

GERD in patients w/ esophagitis &/or severe reflux symptoms; healing of gastric ulcers associated w/ NSAIDs. Short-term maintenance of haemostasis & prevention of rebleeding in patients following endoscopy for acute gastric bleeding or duodenal ulcer.

20-40 mg once daily. Reflux esophagitis 40 mg once daily. Reflux symptoms 20 mg once daily. Healing of NSAID-associated gastric ulcers 20 mg once daily. Maintenance of haemostasis & prevention of rebleeding of gastric & duodenal ulcers 80 mg as bolus infusion over 30 min followed by continuous IV infusion of 8 mg/hr for 3 days or 72 hr. Period of parenteral treatment should be followed by gastric acid suppression therapy by 40 mg orally once daily for 4 wk.

Should be taken on an empty stomach: Take at least 1 hr before meals. Swallow whole, do not chew/crush.

Hypersensitivity to esomeprazole or benzimidazole. Concomitant use w/ atazanavir & nelfinavir.

Exclude gastric malignancy before treatment. Pregnancy & lactation.

Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, hypersensitivity reactions (eg, fever, angioedema, anaphylaxis reactions or shock), peripheral edema, hyponatremia, hypomagnesemia, insomnia, agitation, mental confusion, depression, aggression, hallucination, headache, dizziness, paresthesia, drowsiness, taste disturbances, blurred vision, vertigo, bronchospasm, abdominal pain, constipation, diarrhea, flatulence, nausea/vomiting, constipation, dry mouth, increased liver enzyme, hepatitis, liver failure, hepatic encephalopathy, reactions at inj site, dermatitis, pruritus, rash, urticaria, alopecia, photosensitivity, erythema multiforme, SJS, TEN, arthralgia, myalgia, muscle weakness, interstitial nephritis, gynecomastia, fatigue, hyperhidrosis.

Concomitant use w/ ketoconazole, itraconazole, erlotinib, digoxin, diazepam, phenytoin, warfarin, cisapride, tacrolimus, MTX, antiretroviral (atazanavir, nelvinavir), clarithromycin, voriconazole, rifampicin, St. John's wort.

Antacids, Antireflux Agents & Antiulcerants

A02BC05 - esomeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).

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