Simdrol

Methylprednisolone

Collagen & allergic disease, herpetiform & exfoliative dermatitis, SJS, psoriasis; allergic conjunctivitis, keratitis, optic neuritis, iritis; leukemia & lymphoma in adult patients & acute leukemia in childn; ulcerative colitis & Crohn's disease; nephrotic syndrome; rejection of organ transplant; adrenocortical insufficiencies; ITP in adults; rheumatic disease.

Tab Adult 4-48 mg daily. Multiple sclerosis 160 mg daily for 1 wk, followed by 64 mg daily for 1 mth. Alternate-Day Therapy Regimen: 1 tab every 2 days. IM/IV Adult 10-40 mg. May be repeated accordingly. Pulse therapy 30 mg/kg given in at least 30 min. Dose can be repeated every 4-6 hr. Acute exacerbation in multiple sclerosis 160 mg daily for a wk followed by 64 mg daily for a mth. Acute spinal injury 30 mg/kg IV infusion for 15 min followed by 45 min infusion, 5.4 mg/kg/hr for 23 hr. Adjuvant therapy for AIDS related to Pneumocytis carinii 30 mg IV twice daily for 1st-5th day, followed by 30 mg once daily on 6th-10th day, then 15 mg once daily on day 11-21. Childn & infant Adrenocortical insufficiency 117 mcg/kg IM or 3.33 mg/m² daily in 3 divided doses every 3 days, or 39-58.5 mcg/kg or 1.11-1.66 mg/m² once daily. Acute spinal injury 30 mg/kg IV infusion for 15 min followed by 45 min infusion, 5.4 mg/kg/hr for 23 hr.

Should be taken with food.

Hypersensitivity. TB, systemic fungal infections, vaccinia or varicella, herpes simplex keratitis, peptic ulcer, Cushing's syndrome, acute psychosis, recent vaccination.

Patients receiving corticosteroid therapy or in stressful conditions. May mask any signs of infections. Avoid vaccination during treatment. Prolonged use. Avoid abrupt w/drawal. Pregnancy & lactation. Infants, childn.

Prolonged use may cause moon face, fatty deposits in some body parts, muscle weakness, HTN, osteoporosis, reduced glucose tolerance, impaired sex hormone secretion, striae, petechiae, acne, edema, hypokalemia, atrophy of adrenal cortex, vasculitis, peptic ulcer, reduced body immunity, delayed wound healing, growth retardation in childn, glaucoma, cataract, thrombosis, psychosis, allergic reactions, CHF, Na retention.

Cardiac glycosides, cyclosporine, phenobarb, phenytoin, rifampicin, troleandomycin, ketoconazole, anticoagulant, ASA, neuromuscular blocking agent (eg, pancuronium), insulin, antihypertensives, diuretic antagonist, acetazolamide, loop & thiazide diuretic, carbenoxolone.

Corticosteroid Hormones

H02AB04 - methylprednisolone ; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations.

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