Reduction of total & LDL cholesterol levels in patients w/ primary hypercholesterolemia when diet & other nonpharmacological measures result in inadequate response.
Dosage/Direction for Use
Initially, 5-10 mg once daily in the evening. Dosage may be increased at intervals of 4 wk to 40 mg once daily.
Administration
May be taken with or without food: Avoid excessive consumption (>1 L/day) of grapefruit juice.
May increase the anticoagulant effects of warfarin. May increase the risk of myopathy & rhabdomyolysis w/ ciclosporin, erythromycin, gemfibrozil & niacin. Heart activity may be elevated w/ concomitant use of digoxin.
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