Hepatic diseases
Adult: As supportive treatment: Usual dose: 140 mg bid or tid. Dosage and recommended therapeutic indications may vary among individual products or between countries (refer to local detailed product guidelines).
Indications and Dosage
Oral
Hepatic diseases Adult: As supportive treatment: Usual dose: 140 mg bid or tid. Dosage and recommended therapeutic indications may vary among individual products or between countries (refer to local detailed product guidelines).
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Administration
Should be taken with food.
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Contraindications
Hypersensitivity.
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Special Precautions
Pregnancy and lactation.
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Adverse Reactions
Significant: Hypersensitivity reactions.
Gastrointestinal disorders: Diarrhoea, dyspepsia, nausea, abdominal pain or bloating, flatulence. Metabolism and nutrition disorders: Anorexia. Nervous system disorders: Headache. Skin and subcutaneous tissue disorders: Pruritus. |
Drug Interactions
May increase the serum levels of metronidazole.
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Action
Description:
Mechanism of Action: Silymarin, an active ingredient extracted from the fruit and seeds of milk thistle (Silybum marianum), is claimed to have hepatoprotective and antioxidant properties. It is composed of a complex of flavonolignans, including silibinin (major component), silidianin, and silicristin. Silymarin is believed to protect the liver by stabilising cell membranes, thereby inhibiting the entry of various toxins into liver cells. It may also promote hepatocyte growth and prevent oxidation and inflammation in the liver. Pharmacokinetics: Metabolism: Metabolised in the liver. Excretion: Mainly via bile (>80% as glucuronide and sulfate conjugates); urine (3-7%). Elimination half-life: Approx 6 hours. |
Chemical Structure
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Storage
Store below 30°C.
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ATC Classification
A05BA03 - silymarin ; Belongs to the class of drugs used in liver therapy.
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References
Gillessen A, Schmidt HH. Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review. Adv Ther. 2020;37:1279-1301. doi: 10.1007/s12325-020-01251-y. Accessed 25/04/2023 Anon. Milk Thistle. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 21/03/2023. Buckingham R (ed). Milk Thistle. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/03/2023. Hepavit (Littman Drug Corp). MIMS Philippines. http://www.mims.com/philippines. Accessed 25/04/2023. Legalon (Viatris Pharmaceuticals, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 21/03/2023. Legalon 140 mg Capsules (Madaus GmbH). MIMS Thailand. http://www.mims.com/thailand. Accessed 25/04/2023. Samarin Tablets (Berlin Pharmaceutical Industry Co., Ltd.). MIMS Thailand. http://www.mims.com/thailand. Accessed 25/04/2023.
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