Initially 0.375 mg daily in 3 divided doses, may be increased every 5-7 days to max of 4.5 mg daily. Maintenance: 0.375-4.5 mg daily. TabRenal impairment, CrCl 20-50 mL/min Initially 0.125 mg twice daily (0.25 mg daily) in 2 divided doses. Max daily dose: 2.25 mg, CrCl <20 mL/min Initially 0.125 mg daily single dose. Max daily dose: 1.5 mg. Restless legs syndrome Initially 0.125 mg taken once daily for 2-3 hr before bedtime. May be increased every 4-7 days to a max of 0.75 mg/day in patients requiring additional symptomatic relief. XR tabCrCl 30-50 mL/min Initially 0.375 mg every other day. Max: 2.25 mg/day.
Hallucinations & abnormal behaviour, patients w/ psychotic disorders. Retinal changes in albino rats. Postural hypotension. Sudden onset of sleep & somnolence, dystonia, melanoma, Parkinson's disease, drug w/drawal syndrome, augmentation in restless legs syndrome. Remnants in stool. Monitor BP especially at the beginning of treatment. May adversely affect ability to drive & using machinery. Renal impairment. Pregnancy, lactation & fertility. Childn & adolescent <18 yr.
Other medication affecting plasma protein binding. Medication that inhibit the active renal tubular secretion of basic (cationic) drugs. Selegiline. Levodopa. Amantadine. Co-administration of antipsychotic medicinal products.
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