Adjunctive therapy for the reduction of elevated serum cholesterol in hypercholesterolemia inadequately controlled by diet. Lowers elevated cholesterol in combined hypercholesterolemia & hypertriglyceridemia (not indicated in cases of hypertriglyceridemia is abnormally of most concern). Relief of pruritus associated w/ partial biliary obstruction. As adjunct to rehydration therapy in relieving diarrhea due to bile acid malabsorption associated w/ ileal resection, Crohn's disease, vagotomy & diabetic vagal neuropathy.
Adult Initially 4 g (1 sachet) 2 times daily, increase to 8 g 2 times daily after 2-4 wk. May increase up to 24 g/day as needed. Pruritus due to partial biliary obstruction & primary biliary cirrhosis 4-8 g/day. Bile acid malabsorption-induced diarrhea Initially 4 g 3 times daily w/ subsequent adjustment as needed. Childn 6-12 yr Adjust dose depending on patient's condition.
Hypothyroidism, DM, nephrotic syndrome, dysproteinemia, obstructive liver disease. Periodically measure serum triglyceride. May reduce absorption of vit A, D & K. Prolonged use may produce hyperchloremic acidosis. Pregnancy & lactation.
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