Combination w/ 5-FU & folinic acid as adjuvant treatment of stage III (Duke's C) colon cancer after complete resection of primary tumor. Treatment of metastatic CRC.
Dosage/Direction for Use
IVAdjuvant treatment 85 mg/m2 repated every 2 wk for 12 cycles for 6 mth. Metastatic CRC 85 mg/m2 2 wkly. Administer for 2-6 hr as IV diluted infusion in 250-500 mL of 5% glucose.
Contraindications
Hypersensitivity. Myelosuppression (neutrophils <2 x 109/L) before the 1st treatment cycle; sensory peripheral sensitive neuropathy w/ functional impairment prior to the 1st cycle of treatment; severe renal insufficiency (CrCl <30 mL/min). Lactation.
Sign Out
