Sanbetoin Adverse Reactions

Body as a whole: Anaphylactoid reaction and anaphylaxis.
Central Nervous System: Adverse reactions in this body system are common and are usually dose related. Reactions include nystagmus, ataxia, slurred speech, decreased coordination, and mental confusion. Cerebellar atrophy may occurred in the regulation of elevated Phenytoin levels and/or long-term use of Phenytoin. Dizziness, vertigo, insomnia, transient nervousness, motor twitching, headache, paresthesia, and somnolence have also been observed.
There are also Phenytoin-induced dyskinesias, including chorea, dystonia, tremor, and asterixis, similar to those induced by Phenothiazine and other neuroleptic drugs.
A predominantly sensory peripheral polyneuropathy has been observed in patients receiving long-term Phenytoin therapy.
Connective Tissue System: Coarsening of the facial features, enlargement of the lips, gingival hyperplasia, hypertrichosis, and Peyronie's disease.
Gastrointestinal System: Acute hepatic failure, toxic hepatitis, liver damage, vomiting, nausea, and constipation.
Hematopoietic System: Hematopoietic complications, some fatal, have occasionally been occurred in association with administration of phenytoin. These have included thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, and pancytopenia with or without bone marrow suppression. Macrocytosis and megaloblastic anemia have also occurred. Lymphadenopathy including benign lymph node hyperplasia, pseudolymphoma, lymphoma, and Hodgkin's disease have also occurred.
Immunologic: Hypersensitivity Syndrome (HSS) or Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), systemic lupus erythematosus, periarteritis nodosa, and immunoglobulin abnormalities.
Dermatologic System: Dermatological manifestations, sometimes accompanied by fever, have included scarlatiniform or morbilliform rashes. A morbilliform rash (measles-like) is the most common; other types of dermatitis are seen more rarely. Other more serious forms that may be fatal have included bullous, exfoliative, or purpuric dermatitis, lupus erythematosus, Stevens-John Syndrome, and toxic epidermal necrolysis (TEN).
Special Senses: Taste perversion.
Musculoskeletal System: Bone fractures and osteomalacia have been associated with long term (> 10 years) use of phenytoin by patients with chronic epilepsy. Osteoporosis and other disorders of bone metabolism, such as hypocalcemia, hypophosphatemia and decreased levels of vitamin D metabolites have also been occurred.