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Concomitant treatment with corticosteroids can inhibit the therapeutic effect of Saizen (see Precautions). Moreover, the following substances can influence the efficacy of somatropin: Gonadotropins, estrogens, androgens and anabolic agents.
There are published in vitro data available indicating that somatropin can increase the clearance of substances that are metabolized by the cytochrome P-450 3A4 eg, sexual steroids, corticosteroids, anticonvulsants and cyclosporin. If somatropin is used together with drugs that are metabolized through CYP-450 3A4-dependent liver enzymes, the clinical efficacy of these drugs should be monitored.
Influence on Diagnostic Methods: Treatment with Saizen can lead to increases in the plasma levels of inorganic phosphorus, alkaline phosphatase and IGF-1.
Incompatibilities: No incompatibilities of Saizen with other pharmaceutical preparations are known at present.
