Adult Conventional Dose: 75-90 mg/m
2 IV over 3-5 min repeated at 21-day intervals. High dose:
Small cell lung cancer (previously untreated) 120 mg/m
2 on day 1 every 3 wk.
Non-small cell lung cancer (squamous, large cell & adenocarcinoma previously untreated) 135 mg/m
2 on day 1 or 45 mg/m
2 on days 1, 2 & 3 every 3 wk given as an IV bolus over 3-5 min or as an infusion for up to 30 min.
Advanced breast cancer 135 mg/m
2 in monotherapy & 120 mg/m
2 in combination therapy every 3-4 wk divided over 2-3 successive days.
Papillary carcinoma & carcinoma-in situ 50 mg/mL (diluted w/ saline or distilled sterile water) once wkly for 8 wk. For carcinoma-
in situ, dose may be increased up to 80 mg/50 mL.
Prophylaxis 50 mg/50 mL once wkly for 4 wk, repeated after 11 mth. Retain soln intravesically for 1 hr.
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