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Pharmacology: Erdosteine is classified as a mucolytic drug that pharmacologically works as a mucus diluent drug in the bronchus.
Pharmacodynamics: Erdosteine tends to dilute the secretions or mucus in the respiratory tract (bronchus) to facilitate expectoration. Erdosteine turns into an active metabolite that contains -SH chemical group. This metabolite breaks the -SH group and reduce the elasticity and viscosity of the mucus to help the expectoration.
Pharmacokinetics: Erdosteine is metabolized rapidly into active metabolites that contains the cluster of free thiol, such as N-thiodiglycolylhomocysteine (metabolite I), N-acetylhomocysteine (metabolite II), and homocysteine (metabolite III). The average elimination half-life of erdosteine is 1.4 hours, metabolite I was 1.2 hours and metabolite II was 2.7 hours.
Erdosteine can be absorbed rapidly after oral administration, after a single oral dose, Tmax: 1.2 hours.
Erdosteine pharmacokinetics does not change with repeated administration.
Age does not change the pharmacokinetics of Erdosteine and its metabolites.
In elderly patients with renal failure with creatinine clearance between 25 and 40 ml/min, the pharmacokinetic characteristics of Erdosteine and its metabolites did not show significant differences with healthy elderly subjects.
