Rinclo

Clopidogrel

Reduction of atherothrombotic events in MI, ischaemic stroke or established peripheral arterial disease. Patient suffering from non-ST segment elevation acute coronary syndrome (unstable angina or non-Q-wave MI) in combination w/ ASA.

Adult & elderly 75 mg daily. Non-ST segment elevation acute coronary syndrome (unstable angina or non Q-wave MI) Loading dose: 300 mg then followed by 75 mg once a day w/ ASA 75-325 mg daily.

May be taken with or without food.

Hypersensitivity. Active pathological bleeding eg, peptic ulcer or intracranial haemorrhage. Severe liver impairment. Lactation.

Patients at risk of increased bleeding from trauma, surgery or other pathological conditions; concomitant treatment w/ ASA, NSAIDs, heparin, glycoprotein IIb/IIIa inhibitors, thrombolytics; lesions w/ a propensity to bleed paticularly GI & intraocular; acute MI w/ ST-segment elevation, acute ischaemic stroke (<7 days). Patient w/ renal impairment & moderate hepatic disease who may have bleeding diathesis. Pregnancy.

Severe neutropaenia & thrombocytopaenia, aplastic anaemia; headache, dizziness, paraesthesia, vertigo; GI disturbances; increased bleeding time, decreased platelets; rash, pruritus; leucopenia, decreased neutrophils & eosinophilia; bleeding, GI, eye or intracranial bleeding purpura/bruising/haematoma & epistaxis, haematuria, thrombotic thrombocytopenic purpura; anaphylactoid reactions; confusion, hallucinations; taste disturbance; vasculitis, hypotension; bronchospasm; colitis, pancreatitis; hepatitis; angioedema, bullous dermatitis, erythematous rash, urticaria, eczema, lichen planus; arthralgia, arthritis; glomerulonephritis; fever; abnormal liver function test, increased blood creatinine.

Increased risk of bleeding w/ warfarin, glycoprotein IIb/IIIa inhibitors, ASA, heparin, thrombolytics & NSAIDs.

Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)

B01AC04 - clopidogrel ; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis.

G