Adult >50 kg 600 mg daily, <50 kg 450 mg daily. To be taken as a single dose for 1st 4 wk. For the next 5 mth, usual dose is 600 mg 2 times wkly. Childn 10-20 mg/kg. Max: 600 mg daily as a single dose. Combine w/ INH or ethambutol.
Administration
Should be taken on an empty stomach: Take 1 hr before or 2 hr after meals.
Contraindications
Hypersensitivity. Icterus. Infants.
Special Precautions
Alcoholics. Impaired liver function. 1st 3 mth of pregnancy.
Adverse Reactions
GI effects, abnormal liver function, jaundice, febrile reaction w/ flu-like symptoms. Alteration in kidney function & renal failure (due to hypersensitivity). Skin reactions, eosinophilia, leukopenia, thrombocytopenia, purpura, hemolysis, shock. Red colouring of urine, sputum, tears, staining of soft contact lens.
Sign Out
