Adult & childn >12 yrGonorrhea 250 mg IM as a single dose. Peri-op infection prophylaxis 1 g IV 0.5-2 hr pre-op. Other infections 1-2 g IM/IV every 24 hr or 500 mg-1 g every 12 hr. Max: 4 g daily. Childn <12 yrMeningitis Initially 100 mg/kg IM/IV daily followed by 100 mg/kg daily or 50 mg/kg 12 hrly for 7-14 days. Max: 4 g daily. Otitis media 50 mg/kg IM as a single dose. Max: 1 g. Skin & soft tissue infections 50-75 mg/kg 12 hrly or 25-37.5 mg/kg 12 hrly. Max: 2 g daily. Other serious infections 25-37.5 mg/kg IM/IV 12 hrly. Max: 2 g daily.
Contraindications
Hypersensitivity to cephalosporins. History of anaphylaxis. Concomitant treatment w/ aminoglycosides or diuretics. Renal failure.
Special Precautions
GI disorders. Long-term use. Neonates especially premature infants w/ hyperbilirubinemia. Pregnancy & lactation. Elderly.
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