Renogen Dosage/Direction for Use

Treatment period: The initial recommended dose is 150 IU/kg body weight per week for patients with hemodialysis and 100 IU/kg body weight per week for patients with non-hemodialysis. If the hematocrit per week is increased by less than 0.5 vol%, the dose can be increased by 15~30IU/kg body weight after 4 weeks, but the maximum increased dose shall not exceed 30IU/kg body weight perweek. The hematocrit shall be increased to 30~33 vol%, but not more than 34 vol%.
Maintenance period: If the hematocrit is up to 30~33 vol% or the hemoglobin (Hb) is up to 90 - 120 g/l, the maintenance treatment period can be started. It is recommended to adjust the dose at the end of 12 weeks treatment whose Hb has fallen greater than 1 g/dL below baseline level should have their dose increased according to schedule below. They are then to be followed up for further 4 weeks to observed the Hb response to the dose increase.
Renogen Dosage Schedule: Baseline Hb - Hb at 12 weeks Dose Increase: >1 to < 2 g/dL 15 U/Kg body weight/dose; ≥2 to < 3 g/dL 20 U/Kg Body weight/dose; ≥ 3g/dL 25 U/Kg body weight/dose.