Discontinue treatment if hypersensitivity reactions or irritation occurs. Not indicated for maintenance treatment of melasma. Recurrence of melasma may occur after Refaquin discontinuation; another treatment may be continued as a replacement of Refaquin cream. Avoid sunlight or UV light exposure, apply sunscreen w/ SPF 30 or higher, wear umbrella, hat, & do not consume OC. Avoid application on eyes, nose, or mouth corners. Pregnancy, lactation.