Sign Out
No drug interactions studies have been conducted with Rebif (interferon-β1a) in humans.Interferons have been reported to reduce the activity of hepatic CYP450-dependent enzymes in humans and animals. Caution should be exercised when administering Rebif in combination with medicinal products that have a narrow therapeutic index and are largely dependent on the hepatic CYP450 system for clearance eg, antiepileptics and some classes of antidepressants.
The interaction of Rebif with corticosteroids or adrenocorticotropic hormones (ACTH) has not been studied systematically. Clinical studies indicate that multiple sclerosis patients can receive Rebif and corticosteroids or ACTH during relapses.
Incompatibilities: Not applicable.
